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Background: The purpose of the study was to investigate the value of pretreatment neutrophil-to-lymphocyte ratio (NLR) as a prognostic marker in triple-negative breast cancer (TNBC) and to see its bearing on the clinical and pathological stage of the disease. Methods: This was a retrospective analysis of cases of TNBC treated at our center from 2006 to 2013. The pretreatment complete blood count was recorded from which the NLR was calculated as the percentage of neutrophils divided by the percentage of lymphocytes. The association between pretreatment NLR with the stage of the disease, clinical and pathological lymph node status, and disease-specific survival was analyzed. Results: A total of 208 patients were eligible for the analysis. The median follow-up period was 48 months. The NLR was found to have a strong correlation with the pathological nodal status and the clinical stage (75% cases node-positive in the high NLR group versus 36% in the low NLR group; P < 0.01). At the time of analysis, 74% of our study population was alive and well. There was no significant correlation between the NLR and the overall survival. Conclusions: Based on our study, we conclude that the pretreatment NLR is strongly associated with lymph node metastasis and clinical stage in TNBC patients. It is probably not useful as a prognostic marker, as it does not seem to have any significant bearing on the overall survival.
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The aim of this study was to analyze the prognostic factors in cases of primary CNS lymphoma (PCNSL) treated at our centre. A retrospective review of case records of PCNSL cases treated at our institute between 2005 and 2016 was performed. The prognostic value of age, sex, Serum Albumin, Neutrophil Lymphocyte Ratio (NLR), were assessed with respect to overall survival. Atotal of 32 patients were included in the study. The median NLR of the study population was 3.6. It was observed that patients with a low NLR (NLR≤3.9) had a significantly better median overall survival compared to the high NLR group (NLR>3.9) [58 months vs 15 months; p=0.011]. We found that the NLR is a unique prognostic tool that predicts survival in PCNSL.
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INTRODUCTION: Meta-analyses have shown concurrent chemoradiotherapy (CCRT) provides no survival benefit over radiotherapy in patients of head and neck squamous cell carcinoma (HNSCC) aged over 70 years. This study was performed to determine the adverse-effect profile, compliance, functional and oncological outcomes in patients of HNSCC over 70 years of age treated with CCRT. MATERIALS AND Methods: Retrospective analysis of stage III/IV HNSCC in patients above 70 years of age who received CCRT at our institution (n = 57). Cox-proportional hazards regression model was used for statistical analysis. RESULTS: There were 57 patients of stage III/IV HNSCC who underwent curative CCRT. 61% completed chemotherapy with no deaths and acceptable toxicity. The predictors of recurrence were poorer performance status (P = 0.031) and treatment breaks (P = 0.04). Tube dependence was associated with 2.7 times higher risk of mortality (P = 0.005). CONCLUSION: CCRT should be considered standard of care in those over seventy with good performance status. Patients with tube dependence have a higher risk of persistent disease or treatment related mortality.
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RESUMO Este artigo objetivou descrever o perfil das Internações por Condições Sensíveis à Atenção Primária (ICSAP) nas 22 Regiões de Saúde do Ceará, através de um estudo quantitativo e transversal sobre as hospitalizações ocorridas entre 2010 e 2014. Houve redução das ICSAP nas regiões, com exceção de duas. Na maioria, a ampliação da cobertura da Estratégia Saúde da Família gerou redução na proporção de ICSAP. Entretanto, é necessário um compromisso mais contundente com relação à sua qualidade, à consolidação do processo de regionalização e ao desenvolvimento de ações intersetoriais que impactem em outros determinantes de saúde.
ABSTRACT This article aimed to describe the profile of Hospitalizations due to Conditions Sensitive to Primary Care (ICSAP) in the 22 Health Regions of Ceará, through a quantitative and cross-sectional study on hospitalizations between 2010 and 2014. There was a reduction of ICSAP in the regions, except for two. In the majority, the expansion of the coverage of the Family Health Strategy has generated a reduction in the proportion of ICSAP. However, a overwhelming commitment to quality is required, to the consolidation of the regionalization process and to the development of intersectoral actions that impact on other health determinants.
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Objetivo: Caracterizar o estado nutricional, histórico de doenças crônicas, o estilo de vida e perfil socioeconômico de comerciários frequentadores de um restaurante social na cidade de Fortaleza-CE, Brasil. Métodos: A amostragem se deu por conveniência, sendo composta por 156 indivíduos, 71 (45,5%) homens, 85 (54,5%) mulheres, com idade entre 19 e 59 anos. As variáveis analisadas foram: peso, altura, índice de massa corporal, circunferência da cintura, histórico de doenças crônicas; etilismo, tabagismo e atividade física; perfil socioeconômico; consumo alimentar de parte da amostra. Avaliou-se a adequação do consumo com base nas Dietary Reference Intakes e exigências nutricionais do Programa de Alimentação do Trabalhador. Resultados: Observaram-se prevalências elevadas de sobrepeso 49 (31,4%) e obesidade 18 (11,5%), alto índice de sedentarismo 109 (69,9%) e consumo de álcool semanal por 27 (17,4%). 111 (71,2%) indivíduos cursaram até o ensino médio; 104 (66,7%) pertenciam à classe econômica C. 136 (87,2%) não apresentaram histórico pessoal de doenças crônicas ou tabagismo. A avaliação da ingestão alimentar revelou adequação em macronutrientes, fibras, gorduras saturadas e micronutrientes, com sódio excessivo. Conclusão: Caracterizouse o estado nutricional como sendo de alta prevalência de sobrepeso e obesidade, associado a uma elevada adiposidade abdominal; estilo de vida sedentário, com etilismo; e perfil socioeconômico predominantemente C1 e C2. Apesar de o presente estudo apresentar ingestão adequada de micro e macronutrientes, o consumo calórico é excessivo, com base no perfil de inatividade física e excesso de peso.
Objective: Characterize the nutritional status, lifestyle, socioeconomic profile and food consumption of commercial workers customers of a social restaurant in Fortaleza-CE, Brazil. Methods: The convenience sample consisted of 156 individuals, 71 (45.5%) men and 85 (54.5%) women, aged between 19 and 59 years. The variables analyzed were: weight, height, body mass index, waist circumference, history of chronic diseases, alcoholism, smoking and physical activity, family income, education and food intake of a subsample. The adequacy of consumption was assessed by observing the recommendations of the Dietary Reference Intakes (DRI) and nutritional requirements of the Workers? Food Program. Results: We observed high prevalence of overweight 49 (31.4%) and obesity 18 (11.5%), high rate of physical inactivity 109 (69.9%). Alcohol is often consumed weekly by 27 (17.4%). 111 (71.2%) of individuals studied until high school; and 104 (66.7%) belonged to socioeconomic class C. 136 (87,2%) showed no personal history of chronic diseases, or practice of smoking. Dietary intake adequacy revealed adequacy for macronutrients, fiber, saturated fats and micronutrients, with excessive sodium intake. Conclusion: Nutritional status was characterized as high prevalence of overweight and obesity, associated with a high abdominal adiposity, sedentary lifestyle, alcohol consumption and socioeconomic profile predominantly C1 and C2. Although the present study shows an adequate intake of micronutrients and macronutrients, there are excessive caloric intake, based on profile of physical inactivity and overweight.